Tsung Tsin Mission of Hong Kong was established by Basel Evangelical Missionary Society (Hakka Church) in 1847. Rhenish Mission (also known as Basel Mission) was organized by German and Swiss churches. Therefore, Tsung Tsin Mission’s theological tradition and church structure integrated with Lutheran and Religious Reform background. Rev. Lechler and Rev. Hamberg were commissioned to preach in China in 1847. In those years, with the base in Hong Kong, Basel Mission focused the work on Hakka group. They carried out evangelistic work in South China cities and villages, as well as the establishment of churches, schools and hospitals. After years of hard work, Basel Mission gradually expanded in South China. The number of followers increased rapidly. Tsung Tsin Mission was formally established in 1924 (named as “Worship Real God, Advocate Truth Road") which substitutes Basel Mission’s structure. The Hong Kong Synod became independent in 1929 and it remained under Tsung Tsin Mission. In 1948, Tsung Tsin Mission had 25 synods, 167 churches and missionary heritages. The total number of church members reached 20,000. Until 1951, because of the political instability, the Hong Kong Synod was separated with the China Synod. The constitution of the Synod was approved and the Synod started handling the procedures of registration at the government in 1952. On 7 June 1956, Tsung Tsin Mission of Hong Kong was approved by the Legislative Council to become a registered organization, named as “Tsung Tsin Mission of Hong Kong".

Since the independence in 1952, Tsung Tsin Mission of Hong Kong followed its original vision of establishment which is to establish God’s mission through church mission, education and social services. Due to Hong Kong’s rapid urbanization and localization, Tsung Tsin Mission expanded their mission target from Hakka group to different groups of society. It became a local Christian church. By China’s Reform and Opening Policy, Tsung Tsin Mission reconnected with the Mainland Tsung Tsin Mission, set up fund to help its rehabilitation and formed visiting groups which helped to establish mutual exchange and support with the Mainland believers.

Currently, Tsung Tsin Mission of Hong Kong has 26 churches (over 10,000 members). 7 child care centres, 6 kindergartens, 4 primary schools, 6 secondary schools (a total of about 10,600 students), 1 Integrated Services Centre in Shatin, 2 Social Centres For The Elderly and 1 Hostel For The Elderly (a total of about 2,000 members). Tsung Tsin Mission of Hong Kong also collaborates with several local and overseas Christian communities for a more effective and comprehensive Gospel channel.